In the body there is something called SHBG (sex hormone binding globulin) when the body is in imbalance is too high a proportion of the testosterone that is bound to this substance. About 60% of your total testosterone is bound to binding globulin (SHBG), making the male hormone inaccessible to the body to use directly. If one can prevent SHBG from catching up and binding part of the testosterone, one has theoretically a higher proportion of free Testosterone in the blood. Furthermore, there is LH hormone which comes from the pituitary gland and signals the testes in the man to produce testosterone. If one can stimulate the LH production, it will result in increased production signal of testosterone. Testosterone is also converted by the enzyme 5-alpha-reductase into DHT (known to cause hair loss and prostate enlargement at too high levels). If we can reduce this enzyme's impact, we in theory get more free testosterone. Both men and women have testosterone and estrogen in the body. However, the man should have about 10g more testosterone than women to function normally. The body has an enzyme called aromatase that controls the conversion of testosterone to estrogen. Too high a level of estrogen gives, among other things, unwanted fat deposits. Adding a substance that can inhibit the effect of aromatase reduces this risk.
Ingredients Manmaker from contains 3,4divanillyl tetrahydrofuran - nettle extract that works by lowering the level of SHBG (six hormone binding globulin) and thus raising the level of free testosterone in the blood. Today, nettle extracts are generally used to support prostate health, urinary comfort and sexual function. nettle extract seems to work through three mechanisms that can support healthy testosterone levels: inhibit aromatase (reduces the conversion of testosterone to estrogen) Inhibition of 5α-reductase (reduces the conversion of testosterone to DHT) Blocking SHBG (giving more free unbound testosterone in the blood)
Manmaker also contains Broccoli extract rich in indole-3-carbinol (I3C). I3C exhibits hormone balancing effects that can increase the levels of testosterone in some situations. I3C is used to promote the metabolism of estrogenic compounds. It can prevent the levels of estrogen from getting too high or too low. It has also been shown to inhibit the effects of the enzyme aromatase. Researchers from the University of Kansas Medical Center have discovered that IC3 and tamoxifen (prescription estrogen receptor antagonist) both blocked estrogen (via various mechanisms).
Magnesium, the 11th most abundant mineral in the body, is an important compound involved in a number of biochemical reactions, including protein synthesis, muscle contractions, nerve conduction, blood pressure, heart rhythm, blood sugar regulation and much more. Given its different roles in over 300 body functions, Mg is an incredibly simple and absurdly complex mineral:
Magnesium facilitates sleep and suppresses anxiety (perhaps by blocking cortisol, the body's stress hormone). Long and healthy sleep as well as low levels of cortisol are associated with higher levels of free and total testosterone. Magnesium can help facilitate the formation of testosterone directly, and it can also indirectly help increase testosterone by blocking cortisol and improving sleep. So, in addition to becoming stronger and having higher levels of testosterone, you will also likely experience better and longer sleep, Magnesium helps to lower SHBG and thus increases the levels of "free" testosterone.
Fenugreek extract (Fenugreek) - well-known and long-term use since this herb contains over 100 phytochemical ingredients such as furostanol saponoids and steroidal saponoids. Fenugreek has traditionally been used to increase libido and strengthen the immune system. However, the testofen is a unique extract of fenugreek which is standardized into a unique blend of saponin glycosides that Gencor has called Fenuside. These components in Testofen can support healthy sexual desire and vitality, muscle mass, free testosterone levels in men, and help reduce normal symptoms of Andropause in men. A mechanism believed to have been found, the testophen blocks 5-alpha reductase and thus the conversion of testosterone to DHT.
Boron has long been associated with testosterone levels, some research suggests that boron helps the body absorb calcium, which stimulates the production of steroid hormones testosterone and estrogen in men and women. The effects of boron also include increasing serum levels of magnesium, zinc and vitamin D as well as a decrease in estradiol and sex hormone binding globulin (SHBG), both of which inhibit the activity of the testosterone.